This study investigates the effectiveness of amniotic membrane transplantation (AMT) for ocular surface reconstruction in 10 patients with various severe corneal conditions. The patients were divided into three groups based on the cause of their condition. Group A included patients with persistent epithelial defects caused by corneal abscesses, radiation, or chemical burns; group B consisted of patients with epithelial defects and severe stromal thinning or impending perforation from chemical burns or corneal abscesses; and group C had a patient with symblepharon, requiring AMT to promote healing and prevent scarring after surgery.

In group A, AMT successfully promoted corneal healing in four out of five patients, although one experienced a recurrence of the epithelial defect. Some patients required additional surgeries, including limbal transplantation, penetrating keratoplasty, or cataract extraction, for further rehabilitation. In contrast, AMT was not successful in group B, as all cases required urgent tectonic corneal grafts due to the severity of stromal thinning. In group C, the surgery successfully released the symblepharon, promoted epithelialisation, and prevented further adhesions.

The study concludes that AMT can effectively promote corneal healing in patients with persistent epithelial defects and can aid in preventing corneo-conjunctival adhesions after surgery. However, it was not effective in preventing the need for tectonic corneal grafts in patients with severe stromal thinning and impending perforation.

For a detailed review, access the full article in the *British Journal of Ophthalmology*, Volume 83, Issue 4, available at https://bjo.bmj.com/content/83/4/399.