Collagen Cross Linking

Collagen Cross Linking

Collagen Cross Linking

What is a Collagen Cross Linking?

Collagen Cross Linking is a revolutionary treatment designed to address Keratoconus, a condition characterised by the thinning and bulging of the cornea, leading to distorted vision. This procedure promotes the formation of stronger bonds within the corneal tissue and stabilises the shape of the cornea, halting the progression of Keratoconus, and preserving or improving vision.

At Precision Vision London, we specialise in providing advanced eye care solutions, including Collagen Cross Linking, to our patients. Our expert team of ophthalmologists is committed to delivering exceptional care tailored to each individual’s unique needs. With a focus on safety, precision, and patient satisfaction, we offer a comprehensive approach to vision correction.

Surgery Prices starting from just £89.58 per eye/month.

with a £250 deposit for 24 months

Collagen Cross Linking

About Benefits Treatment Process Aftercare


Collagen Cross Linking stands out as the singular treatment capable of halting the advancement of the condition while partially reversing the corneal steepening triggered by the disease. At our clinic, we provide epithelium-off treatment, a method involving the creation of a corneal flap in the delicate outer layer (epithelium) of the cornea. This technique facilitates the deeper penetration of the liquid Riboflavin (Vitamin B12) into the corneal tissue during exposure to UV light. This non-invasive approach not only eliminates the necessity for a corneal graft but also has the potential to address some of the patient’s prescription needs.

The process of photopolymerisation, induced by the addition of Riboflavin under UV light, is pivotal in arresting the progression of the condition. This mechanism generates oxygen radicals, enabling the formation of robust collagen bonds. By strengthening these chemical bonds in the cornea, the procedure effectively augments thickness and stabilises the cornea, thus impeding the disease’s advancement. Notably, this treatment typically requires only a single session to effectuate a lasting change.

To be considered eligible for Collagen Cross Linking, individuals must have progressive Keratoconus that hasn’t reached an advanced stage necessitating a corneal graft. Additionally, candidates must be at least 18 years old. Determination of suitability for treatment will be made by the surgeon following a thorough assessment during the consultation.

Collagen Cross Linking Effect


Mr. Pillai, a distinguished corneal specialist, has been expertly administering Collagen Cross Linking treatment since 2007. This non-surgical procedure is entirely non-invasive, offering patients a gentle and effective solution. Internationally recognised, it is performed in over 500 clinics worldwide, underscoring its widespread acceptance and effectiveness.

One of the significant advantages of Collagen Cross Linking is its ability to obviate the need for a corneal graft, sparing patients from the associated risks and recovery time. By stabilising the fibres within the cornea, this treatment enhances its structural integrity, effectively halting the progression of the disease. Notably, the procedure typically requires only a single session to yield a permanent and lasting change, providing patients with long-term relief and peace of mind.

Treatment Process

Each eye is treated individually, with a one week gap between procedures. The entire procedure is non-invasive and typically lasts about 60 minutes per eye.

Firstly, anaesthetic drops are applied to numb the eye, ensuring patient comfort throughout the treatment. An eyelid guard is then employed to prevent blinking during the procedure. Next, a weak alcohol solution is delicately applied to soften the upper epithelial cells, which are subsequently manually removed by our skilled surgeon.

Following this, a Riboflavin (Vitamin B2) solution is carefully dropped onto the surface of the eye, facilitating the cross-linking process. The eye is then exposed to a controlled amount of UV light. This process of adding drops and exposing the eye to UV light is repeated as necessary.

After the procedure, a protective contact lens is placed in the eye to safeguard it until the first post-operative check. Our specialist nurse will provide detailed instructions regarding precautions and medications essential for aiding your recovery. Your first post-operative check is scheduled four days after treatment to monitor progress and ensure optimal healing.

Collagen Cross Linking Treatment Process


Upon receiving Collagen Cross Linking treatment at our UK clinic, you’ll be provided with an eye cover for the treated eye, along with anti-inflammatory, antibiotic, and hydrating drops. Our staff will instruct you on the appropriate usage of these drops. At the first post-operative check, scheduled 4 to 5 days after treatment, our surgeon will carefully examine the treated eye and remove the protective lens.

During the recovery period, which may last up to a week, patients may experience some discomfort for 2 to 3 days following the treatment. Dry eyes are common during the healing process and are considered a normal part of recovery. Visual fluctuations can persist for 1 to 3 months until the prescription stabilises, at which point new glasses or contact lenses can be fitted.

While most patients experience stability in vision after this period, minor fluctuations may continue for up to six months post-treatment. Regular post-operative checks are necessary throughout the year, starting from 3 months after treatment. These checks can be conducted either at our clinic or at one of our optometrist network partners.

Following treatment, patients can typically resume normal activities, although certain restrictions may apply, which will be discussed during the consultation. Driving is usually permitted once the prescription has stabilised and new glasses or contact lenses have been obtained. For patients using Kerasoft lenses, the waiting period may be reduced to 5 to 10 days before resuming driving activities.

Price Guide

Cross-Linking & INTACS

Consultation Fee – £150

This deposit is taken at the time of booking and is non-refundable

Manual Collagen Cross Linking – £2400 per eye

Cross linking with laser-assisted – £2700 Per eye

A deposit of £250 per eye is required when reserving treatment and is deducted from the final cost.

Corneal Implants (INTACS and Kerarings) – £2750 per eye

A deposit of £500 per eye is required when reserving treatment and is deducted from the final cost.

Specialist Keratoconus ICL – £4450 per eye

Distance correction for complex prescriptions with astigmatism. A deposit of £1250 per eye is required when reserving treatment and is deducted from the final cost.

All Keratoconus Rehabilitation Packages include:

A fully comprehensive consultation with Precision Vision's expert team – including essential eye tests, health checks, dilation, biometry and topographic mapping.
The opportunity to discuss your treatment options with Dr. CT Pillai, Precision Vision’s corneal and refractive specialist.
A personalised treatment plan tailored to your visual and lifestyle needs.
All treatments are conducted using the safest and most advanced technology in the country.
All inclusive 12 month aftercare program.
24-hour post treatment telephone access to Precision Vision's expert team.
All post-operative medication is provided for 1 month after surgery.

Once the aftercare program has been completed, you will be discharged, however, it is recommended that annual check-ups are attended. 

Your 4 step Treatment Plan

Our approach revolves around prioritising your optimal well-being.

Prior to your consultation

Your first point of contact will be with Precision Vision’s highly trained and knowledgeable patient coordinators.


On the day of your treatment, our clinical team will guide you through the process and address any concerns or questions you may have.

Eye Surgery


At Precision Vision, we believe that it is essential to be selective to ensure that every patient has the best treatment to suit their visual and lifestyle needs which is why determining suitability is incredibly important.


Your aftercare begins immediately after treatment when you are taken to the recovery room to relax and, when you are ready to leave, our specialist nurse will examine you before you go home.

Why Chose Precision Vision for a Collagen Cross Linking treatment?

First Class Treatments

As leaders in Keratoconus treatments, we specialise in comprehensive visual rehabilitation. Our tailored treatments aim to halt progression, improve comfort with contact lenses, and offer total vision correction, addressing individual needs with personalised care and specialised procedures. Our goal is to optimise vision and enhance quality of life for every patient.

First Class Surgeons

At Precision Vision London, Dr. CT Pillai, our Medical Director and lead surgeon, stands out as one of the few specialists in the country with dual fellowships in corneal and refractive surgery. With over 30 years of experience as an ophthalmic surgeon, his expertise in treating corneal abnormalities is widely recognised and sought after. Dr. Pillai's dedication to excellence ensures that our patients receive the highest standard of care and expertise available.

First Class Service

At Precision Vision London, we prioritise exceptional care and outcomes for all our patients, consistently exceeding expectations. With all our bespoke treatments available under one roof, we ensure convenience and efficiency. Additionally, our patients benefit from access to the largest independent optometrist network in the country, facilitating convenient and comprehensive aftercare at locations closer to them.

Collagen Cross Linking FAQs

What is Collagen Cross Linking (CXL) treatment?

Collagen Cross Linking (CXL) is a procedure used to treat conditions like keratoconus. It involves applying a riboflavin solution to the cornea, followed by exposure to UV light, strengthening the cornea's collagen fibers to halt the progression of the disease.

Is Collagen Cross Linking safe?

Yes, Collagen Cross Linking is considered a safe and effective treatment for conditions like keratoconus. However, like any medical procedure, it carries some risks, which your ophthalmologist will discuss with you during your consultation.

How long does Collagen Cross Linking treatment take?

The procedure typically takes about 60 minutes per eye. However, this can vary depending on individual factors and the specific technique used by your surgeon.

Is Collagen Cross Linking painful?

Patients may experience some discomfort during and after the procedure, but it is generally well-tolerated. Your surgeon will administer numbing eye drops to minimize any discomfort during the treatment.

How many sessions of Collagen Cross Linking are required?

In most cases, only one session of Collagen Cross Linking is needed to achieve lasting results. However, your ophthalmologist will determine the appropriate treatment plan based on your individual condition and response to the procedure.

What is the recovery process like after Collagen Cross Linking?

The recovery period can vary from person to person but typically lasts about a week. During this time, you may experience some discomfort, dry eyes, and visual fluctuations. Your surgeon will provide detailed post-operative instructions and medications to help manage these symptoms.

Can Collagen Cross Linking improve my vision?

While Collagen Cross Linking is primarily aimed at halting the progression of conditions like keratoconus, some patients may experience improvements in their vision following treatment. However, the extent of improvement can vary depending on individual factors.

Are there any restrictions after Collagen Cross Linking?

Yes, there are typically some restrictions on activities such as swimming and strenuous exercise for a period following Collagen Cross Linking. Your surgeon will provide specific guidelines based on your individual circumstances.

How soon can I resume normal activities after Collagen Cross Linking?

Most patients can resume normal activities within a few days to a week after Collagen Cross Linking, but this can vary depending on individual healing and recovery. Your surgeon will advise you on when it is safe to resume specific activities.

Is Collagen Cross Linking covered by insurance?

Coverage for Collagen Cross Linking can vary depending on your insurance provider and the specific terms of your policy. It's essential to check with your insurance company beforehand to determine coverage and any potential out-of-pocket expenses.